#Hydroxychloroquine

[shdw01]

So what are Trump's options here? Can he overrule FDA and Fauci and start pumping, promoting, administering, etc?

I cant blame Fauci, FDA, or anyone else that is too afraid to give their stamp of approval. If not properly tested and shit hits the fan then that would be chaotic.

I feel like Trump is the only one who doesnt give a shit if he makes a decision (with good intentions) and he is wrong. But does he have any power here?

 

[MrBetitall]

Just another idiotic move by the buffoon in chief. Kind of like using LSD to cure a hangover or meth to cure depression. Untested, unproven, a million side effects. He just doesn't care who he hurts in his drive to get the stock market back to it's record highs before November

 

[3peet]

Whats Trump got to gain for touting this damn drug so hard when everyone in the medical community is against it?

 

[niltes]

it's simple. if it helps, he will take full credit, insult any naysayers, and it would reaffirm
his self claim that he's a genius. if it fails to work (or worse); he will disavow supporting
the drug and blame Obama, clinton, the media, or certain democrats. if his quotes
are brought up by the media, he will accuse them of asking nasty or gotcha questions
while framing his answers that they heard him wrong or he was joking.
trump supporters, fox news, or oan news will support and believe trump's statements.

 

[Railbird]

medical community is for it. The only people against it are "Chyna" and democrats. Stanford, Austrailia, France all have proven it works, along with many cured patients here last 2 weeks

 

[niltes]

also, I don't believe that everyone in the medical community is against the
drug. they would like to test it under controlled conditions to confirm any
benefits while documenting whether its known side effects remain the
same or change when infected. personally, i'd rather get my medical
advice from a stable genius politician rather than people who had
many years of medical schooling + training, decades of experience
dealing with viral issues, and are in communication with medical
personnel who working with virus patients everyday.

certainly if one is in terrible shape and likely to die, then using the
drug should be an option, but using it as a preventive medication
is a huge step.

I think railbird needs some or has taken too much hydroxychloroquine

 

[VIEJODINOSAUR]

also, I don't believe that everyone in the medical community is against the
drug. they would like to test it under controlled conditions to confirm any
benefits while documenting whether its known side effects remain the
same or change when infected. personally, i'd rather get my medical
advice from a stable genius politician rather than people who had
many years of medical schooling + training, decades of experience
dealing with viral issues, and are in communication with medical
personnel who working with virus patients everyday.

certainly if one is in terrible shape and likely to die, then using the
drug should be an option, but using it as a preventive medication
is a huge step.

I think railbird needs some or has taken too much hydroxychloroquine

No worry...that’s just mental illness

 

[michael777]

medical community is for it. The only people against it are "Chyna" and democrats. Stanford, Austrailia, France all have proven it works, along with many cured patients here last 2 weeks

100% correct

 

[niltes]

dr fauci- "the data are really, just, at best, suggestive. So, I think in terms
of science, I don't think we could definitely say it works".

Not what one would call a ringing endorsement.
now if one believes that fauci is only a political hack (for the last 30+ years)
or if one believes that he is in this position because of his experience,
knowledge, and medical acumen; then those divergent opinions
would lend one to have dramatically different respect for his statements
and actions.

to even imply that democrats are rooting for the virus to continue to
expand as a way for hurting trump, is the epitome of political cynicism
and taking conspiracy theories to a whole new level. it's the type of
rhetoric that shows how far apart we are in this country with little
hope of working together on almost anything in the near future.

 

[REDEYE]

I haven't heard a good reason yet why it shouldn't be used and used now

 

[exploited17]

Just another idiotic move by the buffoon in chief. Kind of like using LSD to cure a hangover or meth to cure depression. Untested, unproven, a million side effects. He just doesn't care who he hurts in his drive to get the stock market back to it's record highs before November

Untested and unproven but we know it has a million side effects. lol
All drugs list side effects for legal purposes whether they are real or likely
Watch out everyone and stay in your home or wuflu will get us all
But don't take that drug that might work cause there might be side effects

 

[niltes]

i get the impression the current medical advice is use it at your own risk,
don't expect it help prevent infection, but it might help with symptoms,
and do expect some bothersome side effects.

 

[Seymour]

Whats Trump got to gain for touting this damn drug so hard when everyone in the medical community is against it?

Against it? do some research - everyone is being administered it - problem is some people are damaged beyond return - you need to start it when you first get symptoms - not when your lungs have hours left

Mark Miller @markmillerdakar

A NY Doctor shared his Hydroxy Chloroquine/Azithromycin results.
200mg 2x daily Hydroxy Chloroquine
500mg 1x daily Azithromycin
220mg 1x daily Zinc sulfate

350 patients
• Breathing restored 3-4 hours
• Zero deaths
• Zero hospitalizations
• Zero intubations​

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<time title="Time posted: March 24, 2020 16:56:07 (UTC)" class="dt-updated" pubdate="" datetime="2020-03-24T16:56:07+0000">12:56 PM - Mar 24, 2020</time>

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[Seymour]

Copy and paste from my email..........

​

An online meeting was held last evening with Dr. Wen Hong Zhang discussing the China experience with COVID-19.

There were ~7000 attendees, mostly from the United States.

​

The following are notes provided to me (I was not on the call):

-Predicted number of cases in Shanghai with exponential growth was calculated to be nearly one million by March 1, but social distancing avoided this.

-Cases went down to zero or near zero by late-Feb, and there is now a small second wave from imported cases.

-Key to mitigating spread in Shanghai was doing diagnostic COVID test on every suspected case.

-All patients with positive COVID PCR were admitted to a designated COVID hospital regardless of their level of illness.

-Coinfection was very common with other respiratory bacteria and common cold viruses, and >50% patients were positive for a co-infection with a respiratory organism.

-False negative rate of COVID PCR even with two serial swabs was 10-30%! Next Generation Sequencing for COVID was used as the gold standard.

-RSV, Mycoplasma and Parainfluenza virus also caused similar bilateral CT findings to COVID. Molecular diagnostics was needed, and even two negative PCRs, for suspected cases on CT - they sent Next Gen Sequencing, a PCR to National Lab, a 3rd local PCR, and local PCR in another swab location (e.g. anal) (e.g. sent all 4) before they would r/o COVID.

-Mean incubation was 6.4 days, and patients were quarantined mean 5.5 days from symptom onset, with this approach the "curve" was 1 month in duration.

-Hydroxychloroquine is in a multicenter RCT in China and will be published "very soon".

-LDH and D-Dimer was associated with development of ARDS.

-He felt there is a narrow window between positive CT findings and deterioration to ARDS, where corticosteroids have been helpful and further studies are required to investigate this.

-Approximately 5% of patients will need ICU level care, and mortality depends on availability of ICU.

-How to protect medical personnel - China protocol:

1) Standardized process in terms of patient care areas and flow.

2) PPE - double-layer gloves, double-layer shoe covers, isolation gown, masks, goggles, etc. "The most important is to cover the head"

3) Positive pressure masks - for aerosol generating procedures.



​

Q&A:

-Time window until infection and test positive? 3d by PCR, and 7d by Serological.

-Who did you test? They abandoned risk factor criteria quickly and just tested anyone with symptoms.

-What is the best test? PCR is better than Antibody test for sensitivity. But the Antibody test is helpful, as PCR can have false negative by week 3. Antibody test is helpful to see the overall population prevalence in terms of patients with mild or no symptoms.

-Does viral RNA degradation of samples happen? Tests are done within 4 hours in China, or frozen at -20C otherwise there is increased false negative.

-What is risk for pregnant women? These cases were mild, and no severe/intubated cases were seen so far in Shanghai (no Wuhan data presented).

-What is the underlying medical conditions that are high risk? Heart disease do the worst - the virus causes myocarditis as well.

-What percentage of patients have antibodies? Every recovered patient tested have found to have antibodies on testing but it is unclear if these are actually protective.

-What is the dosage for hydroxychloroquine? 400mg bid x1d, 400mg po qd. They did not treat with azithromycin due to hepatotoxicity observed.

-What is the risk to health care workers? There were none of his colleagues who went to Wuhan to help that became infected with COVID, and this is attributed to PPE.

-What is the outcome of COVID survivors? Lung fibrosis is definitely less than SARS and most patients had a good long-term outcome.​

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[Seymour]

Dr. Jason Maude| Emergency Medicine

"I understand from the recent experience at hospitals in Paris that now give hydroxychloroquine routinely, is that it doesn't work when given in the late stages of the disease progression - I assume the other organs have started to deteriorate - but it does work extremely well when given in the early stages. In fact, they report a threefold increase in patient throughput with stories of severely ill elderly patients actually recovering in a few days. If we look at the study you cite with the knowledge that the drug is very unlikely to work in those patients who need to go to ICU, how would the numbers look then?

At this stage, there seems to be enough from the various studies, the fact that Belgium and France are now recommending the drug for treatment and that the clinicians there all want to take for preventative purposes, the fact that the Indian Medical Research Council recommends it for preventative use and finally a growing body of anecdotal evidence that it works, to administer it to patients early on.
There has been a lot of criticism of the studies but even the authors would probably not describe them as robust but simply done to help their colleagues around the world learn as soon as possible what appears to be working. This really is the time to listen and learn from others about what works and not wait for the perfect RCT."
​

 

[Dave007inVegas]

A question for all you naysayers.

If you have the virus and your death is assured if you don't take Hydroxychloroquine would you refuse to take it
because the FDA hasn't approved it as a treatment?

Even though it has shown to be effected in many cases.

 

[Dave007inVegas]

^^^

What's wrong squad members? Cat got your tongues?

 

[bmd1803]

A question for all you naysayers.

If you have the virus and your death is assured if you don't take Hydroxychloroquine would you refuse to take it
because the FDA hasn't approved it as a treatment?

Even though it has shown to be effected in many cases.

Very good question ?

 

[Meano]

Just another idiotic move by the buffoon in chief. Kind of like using LSD to cure a hangover or meth to cure depression. Untested, unproven, a million side effects. He just doesn't care who he hurts in his drive to get the stock market back to it's record highs before November

Thats the analogy you come up with? Like using meth to treat depression. Id call you a douche bag but that would be an insult to douche bags. You are so close minded it raises the question that you may be brain dead. You completely lack ability to evaluate any type of issue

 

[Dave007inVegas]

Very good question ?

And ignored by the critics. Go figure. Not a set among em.